1. Certainly. No matter what happens, one side is going to see advantage in using them, whether it's the losing side, or a side which enjoys high levels of technology and WRCs. Furthermore, in the era of the billion dollar (or more) warchest, without nuclear weapons it will be nearly impossible to do any lasting damage to an opponent, so any global war will necessitate their use if anyone actually wants to win.
2. Absolutely not. They're just another tool of warfare, and the "For the Love of God Think of the Children" type of thinking is outdated and obsolete, as the League discovered to their woe in the second Great War.
3. Nothing really, the game has gone too far to suddenly revert to a 2006 mindset.