The Hegemony will be replaced, and a new bloc will rise to preeminence. That's just the way of things. I don't see there being a "Hegemonic" bloc at the helm of Bob for a while though. While C&G or one of the other core Karma blocs may take the top, I can't see them acting in the same manner as the Hegemony.
Hopefully, what we'll see instead though, is 3 or 4 blocs achieving more or less equal power and influence. That would make things much more interesting. You can sort of already see that happening. There are a good number of people who neither agree with Karma or the Hegemony. That's a good thing, I think. A multiplicity of factions and viewpoints will hopefully lead to Planet Bob becoming a much more interesting place, as well as requiring more thought from us as players as to whom we wish to throw our lot in with.
As for the NPO, I'd say a new bloc from them is an inevitable eventuality. No matter how much they are beaten down, they will retain their core. They've been around too long not to, and they will always have friends.