I'm really excited for FOOTBALL to finally start tonight so I thought I would share my upset picks of the week. I go mainly by gut feeling and prejudice and I do no real research so don't get too mad at me. Make fun of me if you need to, I will probably agree with your assessment.
Philadelphia versus St. Louis
I'm not sold on the Dream Team personally. I know you shouldn't pay any attention at all to preseason, but Philly's O-Line looked pretty bad. I think if things come together for them, it won't be this week. Sam Bradford could be a top 5 QB in 5 years, and I think Sims-Walker was a good pick up. I'm on the bandwagon for this pick but I think the Rams win this one by at least a touchdown.
Jacksonville versus Tennessee
Sort of a crap game, but JAX is favored for some reason. I know Chris Johnson missed a lot of practice, but I think he will be productive. Jacksonville is circling the drain in preparation for the move to Los Angeles in a few years. The Titans win this by field goal.
San Diego versus Minnesota
O.K., this is a fan pick. Whats backing me up though is that SD are notoriously slow starting. I don't think McNabb is going to be that bad providing Harvin feels ok and Adrian Peterson is still the best RB in football. Again, a fan pick.
Dallas has a chance to beat the Jets now that they have a real coach. Denver and Oakland is a toss up to me. ( What is with the awful MNF games?)
EDIT: I missed the Tampa Bay Detroit game as a possible. I'm not picking it because I can't bring myself to jump on the DET bandwagon just yet, but it's entirely possible.
Lines taken from http://www.footballlocks.com/nfl_lines.shtml